3-Methoxyeticyclidine (also called methoxieticyclidine and Buy 3-MEO-PCE) is a new dissociative substance that belongs to the arylcyclohexylamine class which reflects dissociative and hallucinogenic effects when administered. Due to its structure it is an analogue of the PCE.
Buy 3-MEO-PCE started to gain popularity in 2010 and is sold in the online chemicals market to unconventional areas as a legal alternative to PCP or ketamine.
Very little data is available on the pharmacological properties, metabolism and toxicity of 3-MeO-PCE, and its use in humans is very short. You are strongly advised to use harm reduction practices if you are using this substance.
Chemistry of Buy 3-MEO-PCE
Buy 3-MEO-PCE, or N-ethyl-1- (3-methoxyphenyl) cyclohexan-1-amine, is classified as an arylcyclohexylamine drug. Ayrlcyclohexylamine drugs are chosen for their structures which include a cyclohexane ring linked to an aromatic ring with an amine group. 3-MeO-PCE buy contains a phenyl ring with a methoxy (CH3-O-) substituent at R3 attached to a cyclohexane ring. An aminoethyl chain -NCH2CH3 is linked to the same carbon (R1) of the cyclohexanone ring. 3-MeO-PCE buy us domestic, like MXE, contains an amino-ethyl chain rather than the amino-methyl chain found in DCK and ketamine. 3-MeO-PCE hole is analogous to MXE, but lacks an R2 substituted ketone. It is also homologous to 3-MeO-PCP but lacks the complementary carbons to complete a piperidine ring.
3-MeO-PCE review largely acts as an NMDA receptor antagonist. NMDA receptors allow electrical signals to pass between neurons in the brain and the spine; for signals to pass, the receiver must be ready. Dissociatives close NMDA receptors by intercepting them. This disconnection of neurons leads to a loss of sensation, difficulty in moving and finally an almost identical equivalent of the famous “k hole”.
3-MeO-PCE erowid has Ki values of 61 nM for the NMDA receptor, 743 nM for the dopamine transporter, 2097 nM for the histamine H2 receptor, 964 nM for the alpha-2A adrenergic receptor, 115 nM for the the serotonin transporter, 4519 nM for the σ1 receptor and 525 nM for the σ2 receptor.
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